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Distribution and Risk Profile of Paroxysmal, Persistent, and Permanent Atrial Fibrillation in Routine Clinical Practice: Insight from the RealiseAF International Registry.
MedLine Citation:
PMID:  22787011     Owner:  NLM     Status:  Publisher    
BACKGROUND: -There is a paucity of international data on the various types of atrial fibrillation (AF) outside of the highly-selected populations from randomized trials. This study aimed to describe patient characteristics, risk factors, comorbidities, symptoms, management strategy, and control of different types of AF in real-life practice. METHODS AND RESULTS: -RealiseAF was a contemporary, large-scale, cross-sectional international survey of patients with AF who had ≥ 1 episode in the last 12 months. Investigators were randomly selected to avoid bias. Among 9,816 eligible patients from 831 sites in 26 countries, 2,606 (26.5%) had paroxysmal, 2,341 (23.8%) had persistent, and 4,869 (49.6%) had permanent AF. As AF progressed from paroxysmal to persistent and permanent forms, the prevalence of comorbidities such as heart failure (32.9, 44.3, and 55.6%), coronary artery disease (30.0, 32.9, and 34.3%), cerebrovascular disease (11.7, 10.8, and 17.6%), and valvular disease (16.7, 21.2, and 35.8%) increased and the prevalence of lone AF decreased. Similarly, there was an increase in mean CHADS(2) score (1.7, 1.8, and 2.2), and more than half (51.0, 56.7, and 67.3%) qualified for oral anticoagulants. Almost 90% of patients received ≥ 1 antiarrhythmic drug, but > 60% had European Heart Rhythm Association symptom scores from II-IV. Moreover, 40.7% of persistent- and 49.8% of permanent AF patients were still in AF with a heart rate > 80 beats per minute. CONCLUSIONS: -This survey disclosed high cardiovascular risks and an unmet need in daily practice for patients with any type of AF, especially those with the permanent form.
Chern-En Chiang; Lisa Naditch-Brûlé; Jan Murin; Marnix Goethals; Hiroshi Inoue; James O'Neill; Jose Silva-Cardoso; Oleg Zharinov; Habib Gamra; Samir Alam; Piotr Ponikowski; Thorsten Lewalter; Mårten Rosenqvist; Philippe Gabriel Steg
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan;
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