Document Detail


Distribution of Poly- and Perfluoroalkyl Substances in Matched Samples from Pregnant Women and Carbon Chain Length Related Maternal Transfer.
MedLine Citation:
PMID:  23777259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although levels of poly- and perfluoroalkyl substances (PFASs) in human maternal and neonatal blood have been widely reported in the literature, maternal-fetal transmission of PFASs with carbon chain length is presently not well understood. In this study, 11 PFASs were analyzed in matched samples, including not only maternal blood (MB, n = 31) and cord blood (CB, n = 30), but also placenta (n = 29), and amniotic fluid (AF, n = 29). Except for perfluorohexanoic acid (PFHxA), the detection frequencies of PFASs were similar among placenta, MB, and CB (> 80% for 8 PFASs, non-detectable for 2 PFASs). Though only perfluorooctanoic acid (PFOA) was frequently detected (> 90%) in AF, with a median concentration of 0.043 ng/mL, other 5 PFASs were also detectable in AF samples with low concentrations (mean: 0.013 to 0.191 ng/mL). This suggests that in addition to blood borne in utero exposure, the fetus is also exposed to low levels of PFASs through AF. Concentrations of PFOA in AF were positively correlated with those in MB (r = 0.738, p < 0.01) and CB (r = 0.683, p < 0.001), suggesting that AF concentration could reflect fetal PFOA exposure during pregnancy and can be used as a biomarker. To clarify the effects of carbon chain length on maternal transfer of PFASs, we calculated maternal transfer efficiencies of PFASs from MB to CB (TMB-CB). A U-shaped trend in TMB-CB of C7-C12 perfluoroalkyl carboxylic acids (PFCAs) with increasing carbon chain length was found in this study for the first time. The U-shaped TMB-CB of PFCAs with carbon chain length is an integrated result of opposite trend of the ratios between MB/placenta and placenta/CB based on carbon chain length. This is the first study to report the occurrence of PFASs in human placenta. The results reported here enabled better understanding of the maternal-fetal transmission of PFASs.
Authors:
Tao Zhang; Hongwen Sun; Yan Lin; Xiaolei Qin; Yanfeng Zhang; Xia Geng; Kurunthachalam Kannan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-18
Journal Detail:
Title:  Environmental science & technology     Volume:  -     ISSN:  1520-5851     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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