| Distribution of the Homeostasis Model Assessment of Insulin Resistance in Mexican children and adolescents. | |
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MedLine Citation:
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PMID: 22065856 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Several cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR) (varying from 2.5 to 4.0) have been suggested for diagnosing insulin resistance in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents.Design and Methods: A total of 6,132 children and adolescents from San Luis Potosi, León, Queretaro, and Durango, which are cities in central and northern Mexico, were enrolled in a population-based cross-sectional study. Eligible participants were apparently healthy children and adolescents aged 6 to 18 years. Pregnancy and the presence of chronic illnesses were exclusion criteria.Results: A total of 3,701 (60.3%) girls and 2,431 (39.7%) boys were included in the present study. In the overall population, the mean body mass index, insulin levels and fasting glucose levels were 21.8±1.3 kg/m2, 7.1±3.2 μU/mL and 86.2±10.0 mg/dL, respectively. The concentrations of insulin and fasting glucose gradually increased from 6 to 12 years of age, whereas the concentrations tended to plateau in the 13- to 18-year-old population. The absolute mean of the HOMA-IR was 2.89±0.7. The HOMA-IR gradually increased with age and reached a plateau at 13 years of age.Conclusions: Because, the insulin concentrations, glucose levels, and HOMA-IR exhibited a gradual increase with age that was not related to obesity, our results suggested that the evaluation of insulin resistance in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point. |
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Authors:
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Celia Aradillas-García; Martha Rodríguez-Morán; Ma Eugenia Garay-Sevilla; Juan M Malacara; Ramon Alberto Rascon-Pacheco; Fernando Guerrero-Romero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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C Aradillas-García, Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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