Document Detail


Distribution of HLA-B*27 alleles in patients with ankylosing spondylitis in Iran.
MedLine Citation:
PMID:  19293478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. OBJECTIVE: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). METHODS: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLA-B*27 subtypes were determined by PCR-SSP. RESULTS: Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls. CONCLUSION: Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnic-group studies.
Authors:
Salomeh Fouladi; Minoo Adib; Mansoor Salehi; Hadi Karimzadeh; Zahra Bakhshiani; Vajiheh Ostadi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Iranian journal of immunology : IJI     Volume:  6     ISSN:  1735-1383     ISO Abbreviation:  Iran J Immunol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282932     Medline TA:  Iran J Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Affiliation:
Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asian Continental Ancestry Group / genetics
Child
Ethnic Groups / genetics
European Continental Ancestry Group / genetics
Gene Frequency / genetics*
HLA-B Antigens / genetics
HLA-B27 Antigen / genetics*
Humans
Iran
Middle Aged
Spondylitis, Ankylosing / genetics*
Young Adult
Chemical
Reg. No./Substance:
0/HLA-B 2705 antigen; 0/HLA-B Antigens; 0/HLA-B*2704 antigen; 0/HLA-B*2707 antigen; 0/HLA-B27 Antigen

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