Document Detail


Distribution of HLA-B alleles in nasopharyngeal carcinoma patients and normal controls in Thailand.
MedLine Citation:
PMID:  12074714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HLA-B frequencies in 54 unrelated nasopharyngeal carcinoma (NPC) patients and 49 healthy random controls in Thailand were investigated by direct DNA sequencing. Similar to previous reports in Chinese NPC patients, HLA-B*4601 was observed at a greater frequency in patients (21/54 (40%)) compared to controls (7/49 (14%). An increase in HLA-B*51012 was also demonstrated. B*51012 was present in 6/54 (11%) NPC patients but was not observed (0%) in controls. B*44032 was associated with a decreased risk. Five out of 54 (9%) NPC patients had B*44032 compared to 14/49 (29%) in the control group.
Authors:
Nattiya Pimtanothai; P Charoenwongse; A Mutirangura; C K Hurley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  59     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-06-20     Completed Date:  2002-12-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  223-5     Citation Subset:  IM    
Affiliation:
Immunology Unit, Department of Microbiology, Georgetown University, Waxhington, DC, USA. Nattiyap@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aged
Alleles*
Carcinoma / genetics*,  pathology
Epstein-Barr Virus Nuclear Antigens / genetics,  metabolism
Female
Gene Frequency / genetics
HLA-B Antigens / genetics*
Haplotypes
Humans
Male
Nasopharyngeal Neoplasms / genetics*,  pathology
Thailand
Chemical
Reg. No./Substance:
0/EBV-encoded nuclear antigen 1; 0/Epstein-Barr Virus Nuclear Antigens; 0/HLA-B Antigens; 0/HLA-B*4601; 0/HLA-B*51012

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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