Document Detail

Distribution of Epidural Saline Upon Injection and the Epidural Volume Effect in Pregnant Women.
MedLine Citation:
PMID:  21336099     Owner:  NLM     Status:  Publisher    
BACKGROUND:: How injected epidural solution is distributed and affects the epidural volume in pregnant women are unclear. METHODS:: Lumbar epidural catheters were placed using the loss-of-resistance technique with saline in eight full-term (39 weeks' gestation) parturients for labor and eight volunteer nonpregnant women. Lumbosacral cerebrospinal fluid volume was measured on thoracic and lumbosacral axial magnetic resonance images. Another image series was obtained after injecting 10 ml saline into the epidural space through the catheter to compare the saline distribution (dural sac coating and exit from foramina) and cerebrospinal fluid volume before and after epidural injection. Dural sac coating was based on observation of epidural saline in the anterior epidural space after injection in axial magnetic resonance images at the pedicle levels from T12 to L5. Saline leakage from the foramina was determined by the same method at six disc levels from T11-T12 to L4-L5. RESULTS:: Significantly fewer images of pregnant women than nonpregnant women showed saline surrounding the dural sac (0 [0-0] vs. 3 [1-4], median [interquartile range]; P < 0.01) and saline leakage from the foramina (0 [0-1] vs. 6 [4-6]; P < 0.01). The mean reduction in cerebrospinal fluid volume was significantly greater in pregnant (8.4 ± 1.4 ml; mean ± SD) than in nonpregnant women (4.6 ± 1.1 ml; P < 0.001). CONCLUSION:: Limited dural sac coating and decreased leakage from the foramina of saline injected into the epidural space may account for the facilitation of longitudinal spread of epidural analgesia in pregnant women. The epidural volume effect is greater in pregnant than in nonpregnant women.
Hideyuki Higuchi; Shunichi Takagi; Eriko Onuki; Nobuko Fujita; Makoto Ozaki
Related Documents :
23755259 - Patterns and outcomes of induction of labour in africa and asia: a secondary analysis o...
23327719 - Is il-17 involved in the interaction between polycystic ovary syndrome and gingival inf...
24093809 - Participant experiences and facilitators and barriers to pill use among men who have se...
25097569 - Association of stat4 gene rs7574865g > t polymorphism with ulcerative colitis risk: evi...
15728279 - Long-term effects of migraine on cognitive function: a population-based study of danish...
21336099 - Distribution of epidural saline upon injection and the epidural volume effect in pregna...
20100809 - Smoking, parent smoking, depressed mood, and suicidal ideation in teens.
22489709 - Obstetrical outcome in women with self-prepared birth plan.
20096899 - Ethnic differences in serum lipoproteins and their determinants in south african women.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Anesthesiology     Volume:  -     ISSN:  1528-1175     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
* Associate Professor, † Lecturer, ‡ Assistant Professor, § Senior Resident, and ∥ Professor Chair, Department of Anesthesiology, Tokyo Women's Medical University, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of Dynamic Intratidal Compliance in a Lung Collapse Model.
Next Document:  Evaluation of the HeartWare HVAD Centrifugal Pump for Right Ventricular Assistance in an In Vitro Mo...