Document Detail


Distribution of C cells in the thyroid gland with pyriform sinus fistula.
MedLine Citation:
PMID:  7838551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pyriform sinus fistula can cause acute thyroiditis or recurrent infection in the neck. This fistula is believed to be a remnant of the branchial apparatus, although its origin has yet to be pinpointed. The spatial distribution of C cells in the thyroid gland was mapped by immunohistologic method in four patients with a pyriform sinus fistula. The C cells were identified immunohistologically with anticalcitonin antibody. The stained calcitonin-positive cells also crossreacted with the antibodies to carcinoembryonic antigen, chromogranin A, and neuron-specific enolase. The C cells were mainly distributed near the end of the fistula, and in three patients their concentration per unit volume of thyroid tissue was found to be inversely proportional to the distance from the end of the fistulas. Comparison of distant locations of the left-sided thyroid lobe in patients and the same region in control subjects showed a similar number of C cells. Thus this limited distribution of C cells suggested that the pyriform sinus fistula was either a remnant of the ultimobranchial body, the result of disturbed migration of the C cell in the fetus, or both.
Authors:
T Himi; A Kataura
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  112     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Sapporo Medical University, School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Branchial Region / embryology,  pathology
Calcitonin / analysis*
Carcinoembryonic Antigen / analysis
Cell Movement
Child
Chromogranin A
Chromogranins / analysis
Epithelium / pathology
Female
Fistula / pathology*
Humans
Immunohistochemistry
Lymphocytes / pathology
Male
Middle Aged
Pharyngeal Diseases / pathology*
Phosphopyruvate Hydratase / analysis
Thyroid Diseases / pathology*
Thyroid Gland / embryology,  metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Chromogranin A; 0/Chromogranins; 9007-12-9/Calcitonin; EC 4.2.1.11/Phosphopyruvate Hydratase

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