Document Detail


Distribution of BCL2 breakpoints in follicular lymphoma and correlation with clinical features: specific subtypes or same disease?
MedLine Citation:
PMID:  12200703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The t(14;18)(q32;q21) translocation is closely associated with follicular lymphoma (FL), and is routinely assessed with molecular methods exploring BCL2 breakpoints for both diagnosis and minimal residual disease (MRD) monitoring. We and others have previously reported new recurrent breakpoints (3'BCL2 and 5'mcr) which could be easily analyzed. In this study, we characterized the BCL2 breakpoints in 113 untreated patients with t(14;18)-positive FL and correlated their location with the location of JH break and with the clinical features. Breakpoints were respectively located at the major breakpoint region (MBR) in 73 cases (65%), at the minor cluster region (mcr) in 10 cases (9%), at 3'BCL2 in 14 cases (12%) and at 5'mcr in seven cases (6%). Finally, the breakpoint could not be located in nine patients (8%). 5'mcr cases were associated with bulky and high-stage disease, with frequent extranodal involvement and bone marrow infiltration. Survival studies did not show any correlation between breakpoint location and clinical outcome. The joining JH6 segment was the most frequently involved whatever the breakpoint location. In conclusion, unusual BCL2 breakpoints are found in about 20% of newly diagnosed follicular lymphomas and their study should be considered in the investigation of BCL2-JH rearrangement. It was not possible, in this series, to demonstrate any correlation between breakpoint location and either initial characteristics of the disease or survival of the patients.
Authors:
G Buchonnet; F Jardin; N Jean; P Bertrand; F Parmentier; S Tison; S Lepretre; N Contentin; P Lenain; A Stamatoullas-Bastard; H Tilly; C Bastard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia     Volume:  16     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-29     Completed Date:  2002-09-26     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1852-6     Citation Subset:  IM    
Affiliation:
INSERM, EMI 9906, IFRMP No. 23, Centre Henri Becquerel, Rouen, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 14 / genetics*
Chromosomes, Human, Pair 18 / genetics*
DNA Primers / chemistry
DNA, Neoplasm / analysis
Female
Humans
Immunoglobulins
Karyotyping
Lymphoma, Follicular / genetics*
Male
Middle Aged
Neoplasm Staging
Neoplasm, Residual / genetics
Polymerase Chain Reaction
Proto-Oncogene Proteins c-bcl-2 / genetics*
Survival Rate
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Neoplasm; 0/Immunoglobulins; 0/Proto-Oncogene Proteins c-bcl-2

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