Document Detail

Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia.
MedLine Citation:
PMID:  9684916     Owner:  NLM     Status:  MEDLINE    
Clinical evidence for a dominant mode of inheritance and anticipation in periodic catatonia, a distinct subtype of schizophrenia, suggests that trinucleotide repeat expansions may be involved in the aetiology of this disorder. Since genes with triplet repeats are putative canditates for causing schizophrenia, we have analysed the polymorphic B33 CTG repeat locus on chromosome 3 in 45 patients with periodic catatonia and 43 control subjects. The B33 CTG repeat locus was highly polymorphic, but all alleles in both the patient and control groups had repeat lengths within the normal range. We conclude that susceptibility to periodic catatonia is not influenced by variation at the B33 CTG repeat locus. Nevertheless, that periodic catatonia displays dominant inheritance and anticipation, characteristic of genetic disorders involving trinucleotide repeats, justifies further screening for triplet repeat expansions in this illness.
D Bengel; U Balling; G Stöber; A Heils; S H Li; C A Ross; G Jungkunz; E Franzek; H Beckmann; P Riederer; K P Lesch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  248     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  1998  
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  IM    
Department of Psychiatry, University of Würzburg, Germany.
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MeSH Terms
Chromosome Mapping
Chromosomes, Human, Pair 3*
Genes, Dominant / genetics
Genetic Predisposition to Disease
Genetic Testing
Middle Aged
Polymorphism, Genetic / genetics*
Schizophrenia, Catatonic / classification,  diagnosis,  genetics*
Trinucleotide Repeats / genetics*

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