Document Detail

Distribution of Alu and L1 repeats in human YAC recombinants.
MedLine Citation:
PMID:  1477474     Owner:  NLM     Status:  MEDLINE    
Evidence is accumulating that the two major families of interspersed repeated human DNA sequences, Alu and L1, are not randomly distributed. However, only limited information is available on their relative long-range distribution. We have analyzed a set of randomly selected, human Chromosome (Chr) 11-specific YAC recombinants constituting a total length of about 2 Mbp for the local and global distribution of Alu and L1 repeats: the data show a strong asymmetry in the distribution of these two repeat classes and give weight, at the long-range molecular level, to previous studies indicating their partition in the human genome; they also suggest a strong tendency for L1 repeats to cluster, with a higher proportion of full-length elements than expected.
B Arveiler; D J Porteous
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  3     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  1992  
Date Detail:
Created Date:  1993-02-05     Completed Date:  1993-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  661-8     Citation Subset:  IM    
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
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MeSH Terms
Base Sequence
Chromosomes, Fungal
Chromosomes, Human, Pair 11
Cloning, Molecular
DNA / genetics
DNA Probes
Molecular Sequence Data
Polymerase Chain Reaction
Recombination, Genetic
Repetitive Sequences, Nucleic Acid*
Reg. No./Substance:
0/DNA Probes; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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