Document Detail

Distribution of 14C-ochratoxin A in the rainbow trout (Salmo gairdneri).
MedLine Citation:
PMID:  3799200     Owner:  NLM     Status:  MEDLINE    
The nephrotoxic mycotoxin ochratoxin A was studied in rainbow trout by whole-body autoradiography and scintillation counting using 14C-labelled toxin. After one single intravenous injection of 10 muCi/fish, corresponding to 160 ng toxin/g body weight, the tissue affinity was studied during an eight day period. As soon as 5 min. after injection the concentration of the radioactivity in the blood had dropped to one tenth of that in the kidney and the urinary bladder. The autoradiograms showed two patterns of blackening in the kidney, one diffuse in the pronephros and one very strong spotty blackening in the opistonephros. In addition to the kidney very high concentrations of radioactivity were also noticed in the bile and the pseudobranch. The muscular tissue of treated trouts contained almost no radioactivity during the whole experiment. Chemical analysis revealed that the radioactivity that could be extracted from the organs was mainly ochratoxin A.
R Fuchs; L E Appelgren; K Hult
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  59     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  220-7     Citation Subset:  IM    
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MeSH Terms
Ochratoxins / metabolism*
Salmonidae / metabolism*
Tissue Distribution
Trout / metabolism*
Reg. No./Substance:
0/Ochratoxins; 303-47-9/ochratoxin A

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