Document Detail


Distributed source modeling of language with magnetoencephalography: application to patients with intractable epilepsy.
MedLine Citation:
PMID:  19552656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine distributed patterns of language processing in healthy controls and patients with epilepsy using magnetoencephalography (MEG), and to evaluate the concordance between laterality of distributed MEG sources and language laterality as determined by the intracarotid amobarbital procedure (IAP).
METHODS: MEG was performed in 10 healthy controls using an anatomically constrained, noise-normalized distributed source solution (dynamic statistical parametric map, dSPM). Distributed source modeling of language was then applied to eight patients with intractable epilepsy. Average source strengths within temporoparietal and frontal lobe regions of interest (ROIs) were calculated, and the laterality of activity within ROIs during discrete time windows was compared to results from the IAP.
RESULTS: In healthy controls, dSPM revealed activity in visual cortex bilaterally from approximately 80 to 120 ms in response to novel words and sensory control stimuli (i.e., false fonts). Activity then spread to fusiform cortex approximately 160-200 ms, and was dominated by left hemisphere activity in response to novel words. From approximately 240 to 450 ms, novel words produced activity that was left-lateralized in frontal and temporal lobe regions, including anterior and inferior temporal, temporal pole, and pars opercularis, as well as bilaterally in posterior superior temporal cortex. Analysis of patient data with dSPM demonstrated that from 350 to 450 ms, laterality of temporoparietal sources agreed with the IAP 75% of the time, whereas laterality of frontal MEG sources agreed with the IAP in all eight patients.
DISCUSSION: Our results reveal that dSPM can unveil the timing and spatial extent of language processes in patients with epilepsy and may enhance knowledge of language lateralization and localization for use in preoperative planning.
Authors:
Carrie R McDonald; Thomas Thesen; Donald J Hagler; Chad Carlson; Orrin Devinksy; Rubin Kuzniecky; William Barr; Lusineh Gharapetian; Amy Trongnetrpunya; Anders M Dale; Eric Halgren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-06-22
Journal Detail:
Title:  Epilepsia     Volume:  50     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-29     Completed Date:  2009-10-01     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2256-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amobarbital / administration & dosage,  diagnostic use,  pharmacology
Brain Mapping / methods
Cerebral Cortex / physiology,  physiopathology*,  surgery
Epilepsy / diagnosis,  physiopathology*,  surgery
Female
Frontal Lobe
Functional Laterality / drug effects,  physiology*
Humans
Judgment / drug effects,  physiology
Language*
Language Tests
Magnetoencephalography / statistics & numerical data*
Male
Middle Aged
Parietal Lobe / physiology,  physiopathology,  surgery
Preoperative Care
Psychomotor Performance / drug effects,  physiology
Semantics
Temporal Lobe / physiology,  physiopathology
Verbal Behavior / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
K23 NS056091/NS/NINDS NIH HHS; K23 NS056091-04/NS/NINDS NIH HHS; K23NS056091/NS/NINDS NIH HHS; NS18741/NS/NINDS NIH HHS; R01 NS018741/NS/NINDS NIH HHS; R01 NS018741-25/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
GWH6IJ239E/Amobarbital
Comments/Corrections

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