Document Detail


Distributed but convergent ordering of corticostriatal projections: analysis of the frontal eye field and the supplementary eye field in the macaque monkey.
MedLine Citation:
PMID:  1279139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The degree of parallel processing in frontal cortex-basal ganglia circuits is a central and debated issue in research on the basal ganglia. To approach this issue directly, we analyzed and compared the corticostriatal projections of two principal oculomotor areas of the frontal lobes, the frontal eye field (FEF) and the supplementary eye field (SEF). We first identified cortical regions within or adjacent to each eye field by microstimulation in macaque monkeys and then injected each site with either 35S-methionine or WGA-HRP conjugate. We analyzed the corticostriatal projections and also the interconnections of the pairs of cortical areas. We observed major convergence of the projections of the FEF and the SEF within the striatum, principally in the caudate nucleus. In cross sections through the striatum, both projections were broken into a series of discontinuous input zones that seemed to be part of complex three-dimensional labyrinths. Where the FEF and SEF projection fields were both present, they overlapped patch for patch. Thus, both inputs were dispersed within the striatum but converged with one another. Striatal afferents from cortex adjacent to the FEF and the SEF did not show convergence with SEF and FEF inputs, but did, in part, converge with one another. For all pairs of cortical areas tested, the degree of overlap in the corticostriatal projections appeared to be directly correlated with the degree of cortical interconnectivity of the areas injected. All of the corticostriatal fiber projections observed primarily avoided immunohistochemically identified striosomes. We conclude that there is convergence of oculomotor information from two distinct regions of the frontal cortex to the striatal matrix, which is known to project into pallidonigral circuits including the striatonigrocollicular pathway of the saccadic eye movement system. Furthermore, functionally distinct premotor areas near the oculomotor fields often systematically projected to striatal zones adjacent to oculomotor field projections, suggesting an anatomical basis for potential interaction of these inputs within the striatum. We propose that parallel processing is not the exclusive principle of organization of forebrain circuits associated with the basal ganglia. Rather, patterns of both convergence and divergence are present and are likely to depend on multiple functional and developmental constraints.
Authors:
H B Parthasarathy; J D Schall; A M Graybiel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  12     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-11     Completed Date:  1992-12-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4468-88     Citation Subset:  IM    
Affiliation:
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Cerebral Cortex / physiology*
Corpus Striatum / physiology*
Eye Movements
Frontal Lobe / physiology*
Horseradish Peroxidase
Macaca fascicularis
Macaca mulatta
Methionine
Neural Pathways / physiology
Oculomotor Muscles / physiology*
Putamen / physiology
Sulfur Radioisotopes
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Wheat Germ Agglutinins
Grant Support
ID/Acronym/Agency:
EY02866/EY/NEI NIH HHS; EY08890/EY/NEI NIH HHS; T32MH15761/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Sulfur Radioisotopes; 0/Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; 0/Wheat Germ Agglutinins; 63-68-3/Methionine; EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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