Document Detail


Distortion-product otoacoustic emission: early detection in deferoxamine induced ototoxicity.
MedLine Citation:
PMID:  17869044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Deferoxamine therapy in lifelong transfusion-dependent anaemias, as beta-thalassemia major, is associated with an increased risk of ototoxic changes. With increasing survival rates, prevention and/or early detection of ototoxicity are important for providing management options. The predictive value of pure-tone audiometry in early detection of ototoxicity has been questioned, particularly in the higher frequencies. Otoacoustic emissions appear to be more sensitive to cochlear insult than the conventional pure-tone audiometry. The aim of our study was to compare the efficacy of otoacoustic emissions (distortion-product otoacoustic emissions) with that of pure-tone audiometry as method of audiological monitoring. METHODS: Baseline audiometric (0.25-8kHz) and otoacoustic emission testing (distortion-product otoacoustic emissions) was conducted in a group of patients with beta-thalassemia major, 60 of whom met the criteria for inclusion in the study. Comparisons were performed between baseline measurements and those recorded after 20 months. Distortion-product otoacoustic emissions were obtained as DP-grams. The DP-gram amplitude was determined for each child. RESULTS: Threshold changes from baseline were found to be statistically significant from 4 to 8kHz in 68.4% of the subjects (P<0.01). Distortion-product otoacoustic emissions demonstrated a significant threshold shift and a decreased amplitude in the frequencies >3kHz (P<0.05). Furthermore, DP-gram amplitude also reduced significantly at 3kHz (P<0.05) without any similar change in pure-tone audiometry. CONCLUSIONS: As ototoxicity screening tool DP-gram was extremely sensitive and superior to pure-tone audiometry. Their use is recommended for regular monitoring of cochlear function, aiming in prevention of permanent damage.
Authors:
Emilio Delehaye; Saverio Capobianco; Ivano Bruno Bertetto; Francesco Meloni
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-09-14
Journal Detail:
Title:  Auris, nasus, larynx     Volume:  35     ISSN:  0385-8146     ISO Abbreviation:  Auris Nasus Larynx     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708170     Medline TA:  Auris Nasus Larynx     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  198-202     Citation Subset:  IM    
Affiliation:
University Department of Otolaryngology Head and Neck Surgery, viale San Pietro 43, 07100 Sassari, Italy. delemy@tiscali.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alexia, Pure
Child
Deferoxamine / adverse effects*
Female
Humans
Male
Otoacoustic Emissions, Spontaneous / drug effects*
beta-Thalassemia / drug therapy
Chemical
Reg. No./Substance:
70-51-9/Deferoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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