| Distinguishing postganglionic from preganglionic lesions. Studies in rabbits with surgically produced Horner's syndrome. | |
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MedLine Citation:
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PMID: 7103817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that the pupillary response to hydroxyamphetamine hydrobromide eyedrops will separate distal from proximal lesions of the sympathetic pathway from the brain to the eye (the pupil fails to dilate in postganglionic lesions). We studied the pupillary response to hydroxyamphetamine in two groups of rabbits with surgically produced Horner's syndrome. Rabbits in one group had postganglionic lesions. In all animals, a miotic pupil developed ipsilateral to the surgical lesion, and oculosympathetic paresis was confirmed in each by testing pupillary response to topically applied cocaine. In rabbits with postganglionic lesions, hydroxyamphetamine failed to dilate the miotic (Horner's) pupils as well as it dilated the normal pupils, while in rabbits with preganglionic lesions both miotic and normal pupils dilated equally. Hydroxyamphetamine appears to be a diagnostically useful drug in Horner's syndrome. |
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Authors:
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B Skarf; J S Czarnecki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of ophthalmology Volume: 100 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1319-22 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamines
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diagnostic use*,
pharmacology Animals Cocaine / diagnostic use, pharmacology Diagnosis, Differential Ganglia, Sympathetic / surgery* Horner Syndrome / diagnosis* Rabbits Reflex, Pupillary / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 50-36-2/Cocaine; 63-90-1/N-hydroxyamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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