Document Detail


Distinctive localization of N- and E-cadherins in rat anterior pituitary gland.
MedLine Citation:
PMID:  17031812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the rat anterior pituitary gland, folliculo-stellate cells aggregate preferably to form pseudofollicles, and each type of hormone-producing cell shows adhesive affinity with particular types of heterologous hormone-producing cells. Distribution of cadherin types in the rat anterior pituitary was examined immunohistochemically to clarify the unique cell arrangements caused by homologous and heterologous affinities among cells. N- and E-cadherins were detected continuously along cell membranes, while P-cadherin was not. N- and E-cadherins showed distinct isolation in localization, with N-cadherins localized in hormone-producing cells of distal and intermediate lobes in various amounts, and E-cadherins limited to folliculo-stellate cells and marginal layer cells facing the residual lumen of Rathke's pouch. A similar distribution of cadherins was observed in cell clusters of primary cultured anterior pituitary cells. These findings suggest that differential expression of cell adhesion molecules may be partially responsible for localization of hormone-producing cells and folliculo-stellate cells.
Authors:
Motoshi Kikuchi; Megumi Yatabe; Ken Fujiwara; Shu Takigami; Atsushi Sakamoto; Tsuyoshi Soji; Takashi Yashiro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  288     ISSN:  1552-4884     ISO Abbreviation:  -     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-25     Completed Date:  2006-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1183-9     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Affiliation:
Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke-shi, Tochigi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cadherins / analysis*
Cell Membrane / chemistry
Cells, Cultured
Immunohistochemistry
Male
Pituitary Gland, Anterior / chemistry*,  cytology
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Cadherins

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