Document Detail

Distinction between malignant L cells and normal mouse fibroblasts by rosette formation with sheep red blood cells.
MedLine Citation:
PMID:  164508     Owner:  NLM     Status:  MEDLINE    
Murine L cell fibroblasts, and derivatives were found to rosette with sheep red blood cells (SRBC). Primary fibroblast explants from the parent murine strain, C3H, did not possess this potential. No rosettes were observed with primary fibroblast explants from C57BL and B10Br mice, with a human fetal lung fibroblast, with baby hamster fibroblasts or their polyoma transormed derivative, or with a cell line, 1T-22, derived from BALB/c mice. Hybridization of 1T-22 and L cells, by Sendai virus-mediated cell fusion, suppressed the rosette potential of the L cell parent. The receptor for SRBC on L cells appears to result from the expression of a recessive characteristic.
J A Hock; M P Dierich; M A Pellegrino; S Ferrone; R A Reisfeld
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  114     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-01     Completed Date:  1975-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1638-40     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Line
Cytopathogenic Effect, Viral
Erythrocytes / immunology
Fibroblasts / immunology*
Hybridization, Genetic
Immune Adherence Reaction*
L Cells (Cell Line) / immunology*
Parainfluenza Virus 1, Human / immunology

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