Document Detail

Distinct, very high frequency oscillations in the activity and amount of active isozyme of lactate dehydrogenase in murine erythroleukaemic cells and a cell-free system.
MedLine Citation:
PMID:  8948125     Owner:  NLM     Status:  MEDLINE    
Electrophoretic and kinetic determinations of the activity of lactate dehydrogenase in murine erythroleukaemic (MEL) cells, sampled at 1 min intervals, reveal distinct oscillations in the activity and amount of active isozyme. Both oscillations have periods in the range of 2-6 min (probably less) and both appear to be rhythmically modulated with respect to period, amplitude and mean. The oscillations also occur in cell-free systems, a fact which throws doubt on the value of studies where it is assumed that such preparations have constant composition.
G M Ferreira; K D Hammond; D A Gilbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  20     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-03     Completed Date:  1997-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  625-33     Citation Subset:  IM    
Department of Medical Biochemistry, Medical School, University of the Witwatersrand, Parktown, Johannesburg, South Africa.
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MeSH Terms
Activity Cycles
Cell-Free System
L-Lactate Dehydrogenase / metabolism*
Leukemia, Erythroblastic, Acute / enzymology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Isoenzymes; EC Dehydrogenase

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