| Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. | |
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MedLine Citation:
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PMID: 22180647 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Plasma contains a variety of long-chain fatty acids (FAs), such that about 35% are saturated and 65% are unsaturated. There are countless examples that show how different FAs impart specific and unique effects, or even opposing actions, on cellular function. Despite these differing effects, palmitate (C16:0) is regularly used to represent "FAs" in cell based experiments. Although palmitate can be useful to induce and study stress effects in cultured cells, these effects in isolation are not physiologically relevant to dietary manipulations, obesity, or the consequences of physiological concentrations of FAs. Hence, authors should avoid conclusions that generalize about "FAs" or "saturated FAs" or "high-fat diet" effects if only a single FA was used in the reported experiments. |
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Authors:
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Matthew J Watt; Andrew J Hoy; Deborah M Muoio; Rosalind A Coleman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 302 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E1-3 Citation Subset: IM |
Affiliation:
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Dept. of Physiology, Monash University, Clayton, Victoria, 3800, Australia. matthew.watt@monash.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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