Document Detail


Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments.
MedLine Citation:
PMID:  22180647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma contains a variety of long-chain fatty acids (FAs), such that about 35% are saturated and 65% are unsaturated. There are countless examples that show how different FAs impart specific and unique effects, or even opposing actions, on cellular function. Despite these differing effects, palmitate (C16:0) is regularly used to represent "FAs" in cell based experiments. Although palmitate can be useful to induce and study stress effects in cultured cells, these effects in isolation are not physiologically relevant to dietary manipulations, obesity, or the consequences of physiological concentrations of FAs. Hence, authors should avoid conclusions that generalize about "FAs" or "saturated FAs" or "high-fat diet" effects if only a single FA was used in the reported experiments.
Authors:
Matthew J Watt; Andrew J Hoy; Deborah M Muoio; Rosalind A Coleman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  302     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-02-14     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Cells, Cultured
Dietary Fats / adverse effects
Endoplasmic Reticulum Stress
Fatty Acids / adverse effects,  blood,  metabolism*
Fatty Acids, Unsaturated / adverse effects,  blood,  metabolism
Humans
Palmitic Acid / adverse effects,  blood,  metabolism
Publications / standards*
Research Design
Grant Support
ID/Acronym/Agency:
R01 DK059935/DK/NIDDK NIH HHS; R01 DK089312/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 2V16EO95H1/Palmitic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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