Document Detail

Distinct roles of osteopontin fragments in the development of the pulmonary involvement in sarcoidosis.
MedLine Citation:
PMID:  11976896     Owner:  NLM     Status:  MEDLINE    
Osteopontin (OPN) is a secreted glycoprotein with cell adhesive and chemoattractive functions and is expressed in granulomas of sarcoidosis. It is well documented that full-length OPN (F-OPN) is susceptible to proteolytic fragmentation resulting in carboxyl-terminal OPN (C-OPN). We have previously revealed that C-OPN suppresses cell adhesion mediated by F-OPN. However, the implication of F-OPN and C-OPN in the progression of pulmonary involvement in sarcoidosis has not yet been elucidated. In this study, we demonstrated that (l) OPN was expressed in granulomas of sarcoidosis, (2) plasma F-OPN level in patients with sarcoidosis, especially in stage II patients, was significantly elevated compared with those of the controls, (3) plasma C-OPN levels in patients of stages 0, I, and III were significantly higher than those of the controls, and (4) in vitro recombinant F-OPN induces macrophage migration and that C-OPN inhibits cell migration mediated by F-OPN. These results suggest that F-OPN may promote granuloma formation in sarcoidosis, while C-OPN may suppress it. Thus, OPN and its fragment may play distinct roles in the development of sarcoidosis.
K Maeda; K Takahashi; F Takahashi; N Tamura; M Maeda; S Kon; T Uede; Y Fukuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lung     Volume:  179     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  2001  
Date Detail:
Created Date:  2002-04-26     Completed Date:  2002-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-91     Citation Subset:  IM    
Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Case-Control Studies
Cell Adhesion
Lung / metabolism
Lymph Nodes / metabolism
Middle Aged
Sarcoidosis, Pulmonary / etiology*
Sialoglycoproteins / blood,  chemistry,  physiology*
Reg. No./Substance:
0/SPP1 protein, human; 0/Sialoglycoproteins; 106441-73-0/Osteopontin

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