Document Detail


Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy.
MedLine Citation:
PMID:  17728360     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.
Authors:
Bernd Weber; Eileen Luders; Jennifer Faber; Sabine Richter; Carlos M Quesada; Horst Urbach; Paul M Thompson; Arthur W Toga; Christian E Elger; Christoph Helmstaedter
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-08-29
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  130     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-05     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  3149-54     Citation Subset:  AIM; IM    
Affiliation:
Department of Epileptology, University of Bonn, Germany. bernd.weber@ukb.uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Atrophy / pathology
Brain Mapping / methods
Corpus Callosum / pathology*
Epilepsy, Temporal Lobe / pathology*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
AG016570/AG/NIA NIH HHS; EB01651/EB/NIBIB NIH HHS; HD050735/HD/NICHD NIH HHS; NS049194/NS/NINDS NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642-11/RR/NCRR NIH HHS; R01 HD050735-02/HD/NICHD NIH HHS; R21 RR019771-02/RR/NCRR NIH HHS; RR019771/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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