| Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy. | |
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MedLine Citation:
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PMID: 17728360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity. |
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Authors:
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Bernd Weber; Eileen Luders; Jennifer Faber; Sabine Richter; Carlos M Quesada; Horst Urbach; Paul M Thompson; Arthur W Toga; Christian E Elger; Christoph Helmstaedter |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-08-29 |
Journal Detail:
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Title: Brain : a journal of neurology Volume: 130 ISSN: 1460-2156 ISO Abbreviation: Brain Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-02-05 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0372537 Medline TA: Brain Country: England |
Other Details:
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Languages: eng Pagination: 3149-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Epileptology, University of Bonn, Germany. bernd.weber@ukb.uni-bonn.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Atrophy / pathology Brain Mapping / methods Corpus Callosum / pathology* Epilepsy, Temporal Lobe / pathology* Female Humans Magnetic Resonance Imaging Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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AG016570/AG/NIA NIH HHS; EB01651/EB/NIBIB NIH HHS; HD050735/HD/NICHD NIH HHS; NS049194/NS/NINDS NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642-11/RR/NCRR NIH HHS; R01 HD050735-02/HD/NICHD NIH HHS; R21 RR019771-02/RR/NCRR NIH HHS; RR019771/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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