Document Detail

Distinct properties of Thy-1 antibodies elicited in rats by immunization with mouse brain.
MedLine Citation:
PMID:  330171     Owner:  NLM     Status:  MEDLINE    
Rats are known to possess antigenic determinants related to the Thy-1.1 allele. Immunization of rats with brain homogenates from mice carrying either the Thy-1.1 or the Thy-1.2 alleles resulted in the production antisera which were cytotoxic for thymus cells of both strains of mice. Lymph node, spleen and cortisone-resistant thymus cells were refractory to the cytotoxic effect of rat anti-mouse brain sera. Peripheral lymphocytes were fully capable of absorbing the cytotoxic activity of the sera on thymus cells, although the concentration of the antigen on their cell surface was considerably less than on thymus cells. Blocking experiments with allo- and xenoantisera to Thy-1 antigens suggested that the antigen detected by rat anti-mouse brain sera is related to the Thy-1 system. The Thy-1 specificity detected by rat antisera seems to differ from previously described Thy-1 antigens in that it attains a high concentration on thymus cells but is relatively deficient in its expression on peripheral T cells.
R Rabinowitz; Y Sharav; M Schlesinger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of immunology     Volume:  7     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  IM    
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MeSH Terms
Antibody Formation*
Antilymphocyte Serum / pharmacology
Binding, Competitive
Brain / immunology*
Cortisone / pharmacology
Cytotoxicity Tests, Immunologic
Immunosorbent Techniques
Mice, Inbred AKR
Mice, Inbred BALB C
Mice, Inbred C3H
T-Lymphocytes / immunology
Thymus Gland / immunology*
Reg. No./Substance:
0/Antilymphocyte Serum; 53-06-5/Cortisone

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