Document Detail


Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment.
MedLine Citation:
PMID:  19199357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo-parieto-occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia.
Authors:
Yoshiyuki Hosokai; Yoshiyuki Nishio; Kazumi Hirayama; Atsushi Takeda; Toshiyuki Ishioka; Yoichi Sawada; Kyoko Suzuki; Yasuto Itoyama; Shoki Takahashi; Hiroshi Fukuda; Etsuro Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  854-62     Citation Subset:  IM    
Copyright Information:
(c) 2009 Movement Disorder Society.
Affiliation:
Department of Radiological Technology and Science, School of Health Science, Tohoku University, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Brain Mapping*
Cerebrovascular Circulation
Cognition Disorders / etiology*,  radionuclide imaging*
Female
Fluorodeoxyglucose F18 / metabolism
Glucose / metabolism*
Humans
Male
Middle Aged
Neuropsychological Tests
Parkinsonian Disorders / complications*,  radionuclide imaging*
Positron-Emission Tomography
Severity of Illness Index
Statistics as Topic
Chemical
Reg. No./Substance:
50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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