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Distinct patterns of cleavage and translocation of cell cycle control proteins in CD95-induced and p53-induced apoptosis.
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MedLine Citation:
PMID:  12923319     Owner:  NLM     Status:  MEDLINE    
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction (R) point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However, as cells with defective in CD95 signaling pathway are still sensitive to p53-induced apoptosis, CD95 cannot be the sole factor resulting in apoptosis. In addition, unlike p53-induced apoptosis, the relationship between CD95-mediated apoptosis and the cell cycle is not clearly understood. It would therefore be worth investigating whether CD95-mediated cell death is pertinent with p53-induced apoptosis in view of cell cycle related molecules. In this report, biochemical analysis showed that etoposide-induced apoptosis caused the induction and the nuclear translocation of effector molecules involved in G1 cell cycle checkpoint. However, there was no such translocation in the case of CD95-mediated death. Thus, although both types of apoptosis involved caspase activation, the cell cycle related proteins responded differently. This argues against the idea that p53-induced apoptosis occurs through the induction of CD95/CD95L expression.
Weon Seo Park; Kyeong Cheon Jung; Doo Hyun Chung; Woo-Dong Nam; Won Jin Choi; Youngmee Bae
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  18     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-04-30     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
Department of Pathology, Kangwon National University College of Medicine, Korea.
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MeSH Terms
Active Transport, Cell Nucleus
Antigens, CD95 / metabolism*
Cell Cycle
Cell Nucleus / metabolism
Coculture Techniques
Dose-Response Relationship, Drug
Etoposide / pharmacology
Flow Cytometry
Jurkat Cells
Nucleic Acid Synthesis Inhibitors / pharmacology
Protein Binding
Protein Transport
Signal Transduction
Tumor Suppressor Protein p53 / metabolism*
Reg. No./Substance:
0/Antigens, CD95; 0/Nucleic Acid Synthesis Inhibitors; 0/Tumor Suppressor Protein p53; 33419-42-0/Etoposide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 8 Year: 2003
Volume: 18 Issue: 4
First Page: 467 Last Page: 472
ID: 3055078
PubMed Id: 12923319
Publisher Item Identifier: 200308467

Distinct patterns of cleavage and translocation of cell cycle control proteins in CD95-induced and p53-induced apoptosis.
Weon Seo Park
Kyeong Cheon Jung
Doo Hyun Chung
Woo-Dong Nam
Won Jin Choi
Youngmee Bae
Department of Pathology, Kangwon National University College of Medicine, Korea.

Article Categories:
  • Research Article

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