| Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. | |
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MedLine Citation:
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PMID: 9357979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The expression patterns of the class I homeogenes HOXB and HOXC clusters in the presence of retinoic acid (RA) were studied in two human small-cell lung cancer (SCLC) cell lines and compared to that of NT2/D1 embryonal carcinoma cells. Contrasting with the sequential 3'-5' induction of the HOX genes observed after RA treatment of embryonic NT2/D1 cells, in the SCLC cells the responding genes (induced or down-regulated) were interspersed with insensitive genes (expressed or unexpressed), while no genomic alteration affected the corresponding clusters. These findings imply that HOX gene regulatory mechanisms are altered in non-embryonic SCLC cells, perhaps reflecting their ability to respond to more diversified stimuli, in relation with their origin from adult tissues. |
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Authors:
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D Flagiello; A Gibaud; B Dutrillaux; M F Poupon; B Malfoy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 415 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-25 Completed Date: 1997-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 263-7 Citation Subset: IM |
Affiliation:
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Institut Curie - CNRS, UMR 147, Paris, France. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/X99679; X99680; X99681; X99682; X99683; X99684; X99685 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Small Cell
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genetics* DNA Primers Electrophoresis, Agar Gel Gene Expression Regulation, Neoplastic / drug effects* Genes, Homeobox* Homeodomain Proteins / biosynthesis, genetics* Humans Neoplasms, Germ Cell and Embryonal / genetics* Polymerase Chain Reaction RNA, Neoplasm / genetics, metabolism RNA-Directed DNA Polymerase / metabolism Tretinoin / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Homeodomain Proteins; 0/RNA, Neoplasm; 302-79-4/Tretinoin; EC 2.7.7.49/RNA-Directed DNA Polymerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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