Document Detail

Distinct patterns of activated neurons throughout the rat midbrain periaqueductal gray induced by chemical stimulation within its subdivisions.
MedLine Citation:
PMID:  7673484     Owner:  NLM     Status:  MEDLINE    
This study provides a map of those neurons in the midbrain periaqueductal gray which are activated by chemical stimulation within different subdivisions of the periaqueductal gray. In pentobarbital anesthetized rats, the expression of the c-FOS protein was detected by immunocytochemistry and was used as a marker of neuronal activity. Microinjections of the gamma-aminobutyric acid (GABAA) receptor antagonist bicuculline (200 pmol in 50 nl) were used to increase selectively the firing rate of neurons originating from the injection site. The pattern of c-FOS immunoreactivity was highly specific for different injection sites. Dorsal injections were characterized by an extensive distribution of c-FOS immunoreactivity along the entire rostrocaudal extent of the periaqueductal gray, while ventral injections produced a much more restricted labeling. Following injection into the dorsal subdivision of the rostral periaqueductal gray, c-FOS immunoreactivity was present bilaterally in the dorsal and dorsolateral subdivisions of the rostral periaqueductal gray and was found in all subdivisions of the caudal periaqueductal gray. Dorsolateral injections at the level of the oculomotor nuclei produced strictly ipsilateral labeling in the dorsal and dorsolateral periaqueductal gray at the level of injection and throughout the ipsilateral half of the periaqueductal gray at more caudal levels. Stimulation in the ventrolateral periaqueductal gray induced FOS in the ventrolateral periaqueductal gray and the adjoining reticular formation. At rostral levels c-FOS immunoreactivity was also seen in the lateral periaqueductal gray but was absent caudal to the injection site. The identified patterns of activity in the periaqueductal gray provide a new basis for the interpretation of the diverse functional consequences of stimulation at periaqueductal gray sites.
J Sandkühler; T Herdegen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  357     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  546-53     Citation Subset:  IM    
II. Physiologisches Institut, Universität Heidelberg, Germany.
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MeSH Terms
Bicuculline / pharmacology*
Biological Markers / chemistry
Neurons / drug effects*
Periaqueductal Gray / cytology,  drug effects*
Proto-Oncogene Proteins c-fos / analysis
Rats, Sprague-Dawley
Stimulation, Chemical
Reg. No./Substance:
0/Biological Markers; 0/Proto-Oncogene Proteins c-fos; 485-49-4/Bicuculline

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