| Distinct pathways for rule-based retrieval and spatial mapping of memory representations in hippocampal neurons. | |
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MedLine Citation:
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PMID: 23325238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hippocampal neurons encode events within the context in which they occurred, a fundamental feature of episodic memory. Here we explored the sources of event and context information represented by hippocampal neurons during the retrieval of object associations in rats. Temporary inactivation of the medial prefrontal cortex differentially reduced the selectivity of rule-based object associations represented by hippocampal neuronal firing patterns but did not affect spatial firing patterns. In contrast, inactivation of the medial entorhinal cortex resulted in a pervasive reorganization of hippocampal mappings of spatial context and events. These results suggest distinct and cooperative prefrontal and medial temporal mechanisms in memory representation. |
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Authors:
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Rapeechai Navawongse; Howard Eichenbaum |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 33 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-17 Completed Date: 2013-04-01 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 1002-13 Citation Subset: IM |
Affiliation:
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Center of Memory and Brain, Boston University, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Association Learning / physiology* Behavior, Animal / physiology Hippocampus / physiology* Male Memory / physiology* Neurons / physiology* Rats Rats, Long-Evans Space Perception / physiology |
| Grant Support | |
ID/Acronym/Agency:
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MH094263/MH/NIMH NIH HHS; P50 MH094263/MH/NIMH NIH HHS; R01 MH051570/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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