Document Detail


Distinct pathways for rule-based retrieval and spatial mapping of memory representations in hippocampal neurons.
MedLine Citation:
PMID:  23325238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hippocampal neurons encode events within the context in which they occurred, a fundamental feature of episodic memory. Here we explored the sources of event and context information represented by hippocampal neurons during the retrieval of object associations in rats. Temporary inactivation of the medial prefrontal cortex differentially reduced the selectivity of rule-based object associations represented by hippocampal neuronal firing patterns but did not affect spatial firing patterns. In contrast, inactivation of the medial entorhinal cortex resulted in a pervasive reorganization of hippocampal mappings of spatial context and events. These results suggest distinct and cooperative prefrontal and medial temporal mechanisms in memory representation.
Authors:
Rapeechai Navawongse; Howard Eichenbaum
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-04-01     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1002-13     Citation Subset:  IM    
Affiliation:
Center of Memory and Brain, Boston University, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Association Learning / physiology*
Behavior, Animal / physiology
Hippocampus / physiology*
Male
Memory / physiology*
Neurons / physiology*
Rats
Rats, Long-Evans
Space Perception / physiology
Grant Support
ID/Acronym/Agency:
MH094263/MH/NIMH NIH HHS; P50 MH094263/MH/NIMH NIH HHS; R01 MH051570/MH/NIMH NIH HHS
Comments/Corrections

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