| Distinct opioid circuits determine the palatability and the desirability of rewarding events. | |
| | |
MedLine Citation:
|
PMID: 19597155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It generally is assumed that a common neural substrate mediates both the palatability and the reward value of nutritive events. However, recent evidence suggests this assumption may not be true. Whereas opioid circuitry in both the nucleus accumbens and ventral pallidum has been reported to mediate taste-reactivity responses to palatable events, the assignment of reward or inventive value to goal-directed actions has been found to involve the basolateral amygdala. Here we found that, in rats, the neural processes mediating palatability and incentive value are indeed dissociable. Naloxone infused into either the ventral pallidum or nucleus accumbens shell blocked the increase in sucrose palatability induced by an increase in food deprivation without affecting the performance of sucrose-related actions. Conversely, naloxone infused into the basolateral amygdala blocked food deprivation-induced changes in sucrose-related actions without affecting sucrose palatability. This double dissociation of opioid-mediated changes in palatability and incentive value suggests that the role of endogenous opioids in reward processing does not depend on a single neural circuit. Rather, changes in palatability and in the incentive value assigned to rewarding events seem to be mediated by distinct neural processes. |
| | |
Authors:
|
K M Wassum; S B Ostlund; N T Maidment; B W Balleine |
Related Documents
:
|
1148875 - Partial klüver-bucy syndrome produced by destroying temporal neocortex or amygdala. 16720395 - Are capuchin monkeys (cebus apella) inequity averse? 19955785 - Genetic variation in dopaminergic reward in humans. 18059435 - The influence of subthalamic nucleus lesions on sign-tracking to stimuli paired with fo... 7506975 - Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of t... 15641075 - Intake of purine-rich foods, protein, and dairy products and relationship to serum leve... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-07-13 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-08-11 Completed Date: 2009-09-28 Revised Date: 2012-06-20 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 12512-7 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90024, USA. kwassum@ucla.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Feeding Behavior / physiology* Food Deprivation / physiology Food Preferences / physiology* Globus Pallidus / drug effects, metabolism, physiology Male Naloxone / pharmacology Narcotic Antagonists / pharmacology Neural Pathways / physiology Nucleus Accumbens / drug effects, metabolism, physiology Rats Rats, Long-Evans Receptors, Opioid / antagonists & inhibitors, metabolism, physiology* Reward* |
| Grant Support | |
ID/Acronym/Agency:
|
DA05010/DA/NIDA NIH HHS; DA09359/DA/NIDA NIH HHS; MH56446/MH/NIMH NIH HHS; P50 DA005010/DA/NIDA NIH HHS; T32MH017140/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Narcotic Antagonists; 0/Receptors, Opioid; 465-65-6/Naloxone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Redefining the p53 response element.
Next Document: Legumes regulate Rhizobium bacteroid development and persistence by the supply of branched-chain ami...