Document Detail


Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
MedLine Citation:
PMID:  1672454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracellular recordings were made from neurons of rat lateral amygdala, nucleus accumbens, and striatum in vitro. Synaptic potentials mediated by gamma-aminobutyric acid and by excitatory amino acids were isolated pharmacologically by using receptor antagonists, and their amplitudes were used as a measure of transmitter release. Muscarine and acetylcholine inhibited the release of both gamma-aminobutyric acid and excitatory amino acids, but measurements of the dissociation equilibrium constants for the antagonists pirenzepine, 11-(2-[(diethylamino)methyl]-1-piperidinyl)acetyl-5,11-dihydro-6H-pyrido [2,3-b][1,4]benzodiazepine-6-one, methoctramine, and hexahydrosiladifenidol indicated clearly that different muscarinic receptors were involved (M1 and probably M3, respectively). The differential localization of distinct muscarinic receptor subtypes on terminals releasing the major inhibitory and excitatory transmitters of the brain could be exploited therapeutically in some movement disorders and Alzheimer disease.
Authors:
S Sugita; N Uchimura; Z G Jiang; R A North
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  88     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-25     Completed Date:  1991-04-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2608-11     Citation Subset:  IM    
Affiliation:
Vollum Institute, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Descriptor/Qualifier:
6-Cyano-7-nitroquinoxaline-2,3-dione
Amygdala / physiology
Animals
Brain / drug effects,  physiology*
Corpus Striatum / physiology
Diamines / pharmacology
Glutamates / metabolism*,  pharmacology
Kinetics
Muscarine / pharmacology*
Neurons / drug effects,  physiology*
Nucleus Accumbens / physiology
Organ Specificity
Parasympatholytics / pharmacology*
Pirenzepine / analogs & derivatives,  pharmacology*
Quinoxalines / pharmacology*
Rats
Receptors, Muscarinic / drug effects,  physiology*
Synapses / drug effects,  physiology
gamma-Aminobutyric Acid / metabolism*,  pharmacology
Grant Support
ID/Acronym/Agency:
DA03161/DA/NIDA NIH HHS; MH40416/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Diamines; 0/Glutamates; 0/Parasympatholytics; 0/Quinoxalines; 0/Receptors, Muscarinic; 102394-31-0/otenzepad; 104807-46-7/methoctramine; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 28797-61-7/Pirenzepine; 300-54-9/Muscarine; 56-12-2/gamma-Aminobutyric Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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