Document Detail

Distinct mechanisms determine organ left-right asymmetry patterning in an uncoupled way.
MedLine Citation:
PMID:  24464475     Owner:  NLM     Status:  Publisher    
Disruption of Nodal in the lateral plate mesoderm (LPM) usually leads to left-right (LR) patterning defects in multiple organs. However, whether the LR patterning of organs is always regulated in a coupled way has largely not yet been elucidated. In addition, whether other crucial regulators exist in the LPM that coordinate with Nodal in regulating organ LR patterning is also undetermined. In this paper, after briefly summarizing the common process of LR patterning, the most puzzling question regarding the initiation of asymmetry is considered and the divergent mechanisms underlying the uncoupled LR patterning in different organs are discussed. On the basis of cases in which different organ LR patterning is determined in an uncoupled way via an independent mechanism or at a different time, we propose that there are other critical factors in the LPM that coordinate with Nodal to regulate heart LR asymmetry patterning during early LR patterning. Also watch the Video Abstract.
Sizhou Huang; Wenming Xu; Bingyin Su; Lingfei Luo
Related Documents :
3114045 - Parallel pathways of potassium transport in the alga hydrodictyon reticulatum. effects ...
18468985 - Arabidopsis thaliana leaves with altered chloroplast numbers and chloroplast movement e...
22039475 - Simulation of near-infrared light absorption considering individual head and prefrontal...
22092985 - Effects of frequency on gross efficiency and performance in roller ski skating.
21353065 - A comparison of conductive textile-based and silver/silver chloride gel electrodes in e...
18451735 - Adaptation mechanisms, eccentricity profiles, and clinical implementation of red-on-whi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-25
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  -     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 WILEY Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A combined nutritional-behavioral-physical activity intervention for the treatment of childhood obes...
Next Document:  Single or combined effects of Lactobacillus sakei and inulin on growth, non-specific immunity and Ig...