| Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS. | |
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MedLine Citation:
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PMID: 20599280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or viral clearance from the brain, whereas, depletion of splenic marginal dendritic cells impaired this response and enhanced morbidity/mortality. Selective depletion of brain perivascular macrophages also suppressed this response without altering viral clearance. Thus, two anatomically distinct phagocytic populations regulate VSV encephalitis in a non-redundant fashion although neither population is essential for viral clearance in the CNS. |
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Authors:
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Christina D Steel; Woong-Ki Kim; Larry D Sanford; Laurie L Wellman; Sandra Burnett; Nico Van Rooijen; Richard P Ciavarra |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 226 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-10-06 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 81-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA. steelcd@evms.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Bone Density Conservation Agents / adverse effects, agonists Central Nervous System / pathology* Clodronic Acid / adverse effects Disease Models, Animal Encephalitis, Viral / drug therapy, immunology*, pathology* Flow Cytometry / methods Granulocytes / drug effects, metabolism Green Fluorescent Proteins / genetics Macrophages / classification*, drug effects, physiology* Mice Mice, Nude Mice, Transgenic Peritoneum / drug effects, pathology Tacrolimus / analogs & derivatives, pharmacology Vesiculovirus / pathogenicity |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI048700-03/AI/NIAID NIH HHS; R01AI048700/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/AP20187; 0/Bone Density Conservation Agents; 0/enhanced green fluorescent protein; 10596-23-3/Clodronic Acid; 109581-93-3/Tacrolimus; 147336-22-9/Green Fluorescent Proteins |
| Comments/Corrections | |
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