| Distinct immune response induced by peptidoglycan derived from Lactobacillus sp. | |
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MedLine Citation:
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PMID: 16419162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To analyze the distinct immune responses induced by Lactobacillus peptidoglycan (PG). METHODS: BALB/c mice were intraperitoneally injected with PG once a day for three consecutive days. Peritoneal macrophage and splenocyte mRNA was extracted and the gene expression profile was studied using high-density oligonucleotide microarrays. Inhibitory effects of Lactobacillus PG on colon tumor tissue were studied in vitro and in vivo. RESULTS: The gene expression profiles revealed that the TLR-NF-kappaB; and Jak-STAT signaling pathways were highly activated. An inflammatory phenotype was induced when peritoneal macrophages were initially exposed to Lactobacillus PG and switched to a more complex phenotype when BALB/c mice were treated with three doses of Lactobacillus PG. A protective physiological inflammatory response was induced after three consecutive days of PG treatment. It was tending toward Th1 dominant immune response. Lactobacillus PG also appeared to induce a significant in vivo anti-colon tumor effect. CONCLUSION: Lactobacillus PG is responsible for certain immune responses induced by Lactobacilli. Anti-tumor effects of Lactobacilli are likely to attribute to the activation of macrophages by PG expressed on the bacterial cell surface. |
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Authors:
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Jin Sun; Yong-Hui Shi; Guo-Wei Le; Xi-Yi Ma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 11 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2006-01-18 Completed Date: 2006-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 6330-7 Citation Subset: IM |
Affiliation:
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Institute of Food Nutrition and Safety, School of Food Science and Technology, Southern Yangtze University, Wuxi 214036, Jiangsu Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Colonic Neoplasms / genetics, metabolism Gene Expression Profiling Immune System / physiology* Inflammation / immunology Lactobacillus / immunology* Macrophages, Peritoneal / immunology Mice Mice, Inbred BALB C Oligonucleotide Array Sequence Analysis Peptidoglycan / immunology* Phenotype Signal Transduction / physiology Spleen / cytology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Peptidoglycan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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