| Distinct endothelial impairment in coronary microvessels from hypertensive Dahl rats. | |
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MedLine Citation:
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PMID: 9453324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension has been linked to an impaired dilator function of the coronary microvascular endothelium in vivo. However, the profile and mechanism of this dysfunction remain obscure. Thus, this study compared diameter responses to acetylcholine (ACH), bradykinin (BKN), and substance P (SP) between coronary microvessels (i.d.=106+/-4 microm) dissected from left ventricles of normotensive and hypertensive Dahl rats (Dahl-NT and Dahl-HT, respectively). Vessels were cannulated and pressurized on glass pipettes at 80 mm Hg, and internal diameters were monitored by videomicroscopy. Coronary microvessels from Dahl-NT and Dahl-HT showed similar dilator responses to ACH (100 pmol/L to 10 micromol/L), with maximal diameter increases of 63+/-5 microm and 63+/-7 microm, respectively (n=31,17). However, only vessels from Dahl-NT showed dilator responses to SP (10 fmol/L to 1 nmol/L) and BKN (100 fmol/L to 10 nmol/L). All dilator responses persisted after N-nitro-L-arginine (10 micromol/L) or indomethacin (10 micromol/L), but were blunted after inhibition of cytochrome P450 by 10 micromol/L octadecynoic acid (n=6-8). These results suggest that: (1) coronary microvessels from Dahl-HT show a unique pattern of endothelial impairment, whereby ACH-induced relaxations persist at a time when dilator responses to SP and BKN are severely blunted, and (2) a cytochrome P450 product, rather than nitric oxide or prostacyclin, may partly mediate the vasodilator responses to ACH, SP and BKN. |
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Authors:
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K M Gauthier-Rein; N J Rusch |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 31 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-20 Completed Date: 1998-02-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 328-34 Citation Subset: IM |
Affiliation:
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Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Bradykinin / pharmacology Coronary Vessels / drug effects, physiology, physiopathology* Cytochrome P-450 Enzyme System / antagonists & inhibitors Diet, Sodium-Restricted Dose-Response Relationship, Drug Endothelium, Vascular / drug effects, physiology, physiopathology* Fatty Acids, Unsaturated / pharmacology Hypertension / physiopathology* Indomethacin / pharmacology Male Microcirculation / drug effects, physiology, physiopathology* Nitroarginine / pharmacology Rats Rats, Inbred Strains Sodium, Dietary Substance P / pharmacology Vasodilation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL-29587/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Sodium, Dietary; 2149-70-4/Nitroarginine; 33507-63-0/Substance P; 51-84-3/Acetylcholine; 53-86-1/Indomethacin; 58-82-2/Bradykinin; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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