Document Detail

Distinct critical cerebellar subregions for components of verbal working memory.
MedLine Citation:
PMID:  22133495     Owner:  NLM     Status:  MEDLINE    
A role for the cerebellum in cognition has been proposed based on studies suggesting a profile of cognitive deficits due to cerebellar stroke. Such studies are limited in the determination of the detailed organisation of cerebellar subregions that are critical for different aspects of cognition. In this study we examined the correlation between cognitive performance and cerebellar integrity in a specific degeneration of the cerebellar cortex: Spinocerebellar Ataxia type 6 (SCA6). The results demonstrate a critical relationship between verbal working memory and grey matter density in superior (bilateral lobules VI and crus I of lobule VII) and inferior (bilateral lobules VIIIa and VIIIb, and right lobule IX) parts of the cerebellum. We demonstrate that distinct cerebellar regions subserve different components of the prevalent psychological model for verbal working memory based on a phonological loop. The work confirms the involvement of the cerebellum in verbal working memory and defines specific subsystems for this within the cerebellum.
Freya E Cooper; Manon Grube; Katharina Von Kriegstein; Sukhbinder Kumar; Philip English; Thomas P Kelly; Patrick F Chinnery; Timothy D Griffiths
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-25
Journal Detail:
Title:  Neuropsychologia     Volume:  50     ISSN:  1873-3514     ISO Abbreviation:  Neuropsychologia     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-05-24     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  0020713     Medline TA:  Neuropsychologia     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Auditory Perception / physiology
Cerebellum / pathology*,  physiopathology
Cognition Disorders / physiopathology*
Magnetic Resonance Imaging
Memory Disorders / physiopathology*
Memory, Short-Term / physiology*
Middle Aged
Neuropsychological Tests
Spinocerebellar Ataxias / genetics,  physiopathology*
Wechsler Scales
Grant Support
084980//Wellcome Trust; 091593//Wellcome Trust; 091681//Wellcome Trust; 096919//Wellcome Trust; NEWBRC-2007-1//Department of Health; //Wellcome Trust

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