| Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. | |
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MedLine Citation:
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PMID: 20471354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photoreceptive, melanopsin-expressing retinal ganglion cells (mRGCs) encode ambient light (irradiance) for the circadian clock, the pupillomotor system, and other influential behavioral/physiological responses. mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones. However, the individual contribution of each photoreceptor class to irradiance responses remains unclear. We address this deficit using mice expressing human red cone opsin, in which rod-, cone-, and melanopsin-dependent responses can be identified by their distinct spectral sensitivity. Our data reveal an unexpectedly important role for rods. These photoreceptors define circadian responses at very dim "scotopic" light levels but also at irradiances at which pattern vision relies heavily on cones. By contrast, cone input to irradiance responses dissipates following light adaptation to the extent that these receptors make a very limited contribution to circadian and pupillary light responses under these conditions. Our data provide new insight into retinal circuitry upstream of mRGCs and optimal stimuli for eliciting irradiance responses. |
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Authors:
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Gurprit S Lall; Victoria L Revell; Hiroshi Momiji; Jazi Al Enezi; Cara M Altimus; Ali D Güler; Carlos Aguilar; Morven A Cameron; Susan Allender; Mark W Hankins; Robert J Lucas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 66 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-06-02 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 417-28 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Faculty of Life Sciences, AV Hill Building, University of Manchester, Manchester M13 9PT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Circadian Rhythm / physiology Humans Light* Light Signal Transduction / physiology* Mice Mice, Transgenic Retina / physiology Retinal Cone Photoreceptor Cells / physiology* Retinal Rod Photoreceptor Cells / physiology* Rod Opsins / physiology* Time Factors Vision, Ocular / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Rod Opsins; 0/melanopsin |
| Comments/Corrections | |
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