| Distinct contributions from the hindbrain and mesenchyme to inner ear morphogenesis. | |
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MedLine Citation:
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PMID: 19896934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A mature inner ear is a complex structure consisting of vestibular and auditory components. Microsurgical ablations, rotations, and translocations were performed in ovo to identify the tissues that control inner ear morphogenesis. We show that mesenchyme/ectoderm adjacent to the developing ear specifically governs the shape of vestibular components - the semicircular canals and ampullae - by conferring anteroposterior axial information to these structures. In contrast, removal of individual hindbrain rhombomeres adjacent to the developing ear preferentially affects the growth and morphogenesis of the auditory subdivision, the cochlear duct, or basilar papilla. Removal of rhombomere 5 affects cochlear duct growth, while rhombomere 6 removal affects cochlear growth and morphogenesis. Rotating rhombomeres 5 and 6 along the anteroposterior axis also impacts cochlear duct morphogenesis but has little effect on the vestibular components. Our studies indicate that discrete tissues, acting at a distance, control the morphogenesis of distinct elements of the inner ear. These results provide a basis for identifying factors that are essential to vestibular and auditory development in vertebrates. |
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Authors:
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Jennifer K Liang; Jinwoong Bok; Doris K Wu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2009-11-06 |
Journal Detail:
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Title: Developmental biology Volume: 337 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 324-34 Citation Subset: IM |
Copyright Information:
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Copyright 2009. Published by Elsevier Inc. |
Affiliation:
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National Institute on Deafness and Other Communication Disorders, 5 Research Court, Rockville, MD 20850, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Chick Embryo Chickens Cochlear Duct / embryology Ear, Inner / embryology* Mesoderm / embryology*, transplantation Morphogenesis* Notochord / embryology Organ Size Rhombencephalon / embryology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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