| Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis. | |
| | |
MedLine Citation:
|
PMID: 17481961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: It has been postulated that nonerosive reflux disease (NERD) and erosive reflux disease (ERD) are 2 distinct entities of gastroesophageal reflux disease. The aim of this study was to compare the clinical characteristics between patients with NERD and those with ERD. METHODS: We prospectively recruited consecutive patients presenting with weekly attacks of heartburn or acid regurgitation. Exclusion criteria included gastric surgery, recent use of nonsteroidal anti-inflammatory drug or proton pump inhibitor, and peptic ulcer disease. Concomitant functional dyspepsia, irritable bowel syndrome, and psychological disorders were documented. Endoscopy, esophageal manometry, acid perfusion test, and 24-hour ambulatory pH monitoring were performed. Risk factors of NERD were determined by multivariate analysis. RESULTS: Two hundred fourteen patients (NERD, 113; ERD, 111) were studied. NERD patients were characterized by higher prevalence of Helicobacter pylori (36.3% vs 18%, P = .005), functional dyspepsia (64.6% vs 42.3%, P = .003), irritable bowel syndrome (44.2% vs 15.3%, P < .001), psychological disorders (9% vs 0.9%, P = .04), and positive acid perfusion test (40.7% vs 19.8%, P = .004). ERD patients had more hiatal hernias (35.1% vs 17.1%, P = .009), higher esophageal acid exposure (total time esophageal pH <4, 4.2% +/- 2.1% vs 5.9% +/- 2.3%; P = .01), and esophageal dysmotility (P < .05). With multivariate analysis, H pylori (odds ratio, 1.8; 95% confidence interval [CI], 1.1-3.2), irritable bowel syndrome (odds ratio, 2.8; 95% CI, 1.6-5.3), and positive acid perfusion test (odds ratio, 1.9; 95% CI, 1.4-2.8) were independent risk factors for NERD. CONCLUSIONS: Patients with NERD and ERD have distinct differences in clinical characteristics. NERD is characterized by higher prevalence of functional gastrointestinal disorders and esophageal acid hypersensitivity. |
| | |
Authors:
|
Justin C Y Wu; Carrian M Y Cheung; Vincent W S Wong; Joseph J Y Sung |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-04 |
Journal Detail:
|
Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 5 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-06-04 Completed Date: 2007-11-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
|
Languages: eng Pagination: 690-5 Citation Subset: IM |
Affiliation:
|
Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong. justinwu@cuhk.edu.hk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Body Mass Index Esophagitis, Peptic / diagnosis*, epidemiology Esophagoscopy Female Gastroesophageal Reflux / diagnosis*, epidemiology Humans Hydrogen-Ion Concentration Irritable Bowel Syndrome / epidemiology Male Manometry Middle Aged Multivariate Analysis Oncogene Proteins v-sis Prospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Oncogene Proteins v-sis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Contractile effect of ghrelin on isolated guinea-pig renal arteries.
Next Document: Serotonin synthesis and uptake in symptomatic patients with Crohn's disease in remission.