Document Detail

Distinct chromosomal rearrangements in subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (Nora lesion).
MedLine Citation:
PMID:  15252309     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Proliferative lesions of the bone surface, such as subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (BPOP, Nora lesion) are currently classified as reactive, proliferative processes that mimic primary neoplasms of bone. METHODS: Cytogenetic analysis was performed on 3 subungual exostoses of the great toe and 2 BPOP lesions of the radius and ulna. RESULTS: A balanced translocation t(X;6) was identified in all cases of subungual exostoses. The chromosomal rearrangements observed in 1 case of BPOP differed from those seen in subungual exostosis. CONCLUSIONS: The presence of chromosomal abnormalities in subungual exostosis and BPOP suggests that these lesions are neoplastic, with a different molecular pathogenesis, and that each is a distinct clinicopathologic entity.
Eduardo Zambrano; Vânia Nosé; Antonio R Perez-Atayde; Mark Gebhardt; M Timothy Hresko; Paul Kleinman; Kathleen E Richkind; Harry P W Kozakewich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  28     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-14     Completed Date:  2004-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1033-9     Citation Subset:  IM    
Department of Pathology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
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MeSH Terms
Bone Neoplasms / genetics*,  pathology,  surgery
Child, Preschool
Chromosomes, Human, Pair 6*
Chromosomes, Human, X*
Hallux / pathology
Osteochondroma / genetics*,  pathology,  surgery
Spectral Karyotyping
Translocation, Genetic / genetics*

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