Document Detail


Distinct cerebral perfusion patterns in FTLD and AD.
MedLine Citation:
PMID:  20819999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We examined the utility of distinguishing between patients with frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD) using quantitative cerebral blood flow (CBF) imaging with arterial spin labeled (ASL) perfusion MRI.
METHODS: Forty-two patients with FTLD and 18 patients with AD, defined by autopsy or CSF-derived biomarkers for AD, and 23 matched controls were imaged with a continuous ASL method to quantify CBF maps covering the entire brain.
RESULTS: Patients with FTLD and AD showed distinct patterns of hypoperfusion and hyperperfusion. Compared with controls, patients with FTLD showed significant hypoperfusion in regions of the frontal lobe bilaterally, and hyperperfusion in posterior cingulate and medial parietal/precuneus regions. Compared with controls, patients with AD showed significant hypoperfusion in the medial parietal/precuneus and lateral parietal cortex, and hyperperfusion in regions of the frontal lobe. Direct comparison of patient groups showed significant inferior, medial, and dorsolateral frontal hypoperfusion in FTLD, and significant hypoperfusion in bilateral lateral temporal-parietal and medial parietal/precuneus regions in AD.
CONCLUSIONS: Doubly dissociated areas of hypoperfusion in FTLD and AD are consistent with areas of significant histopathologic burden in these groups. ASL is a potentially useful biomarker for distinguishing patients with these neurodegenerative diseases.
Authors:
W T Hu; Z Wang; V M-Y Lee; J Q Trojanowski; J A Detre; M Grossman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  75     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-09-27     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  881-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology-2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104-4283, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / physiopathology*,  radionuclide imaging
Brain / blood supply*,  physiopathology*,  radionuclide imaging
Brain Mapping
Cerebrovascular Circulation*
Female
Frontotemporal Lobar Degeneration / physiopathology*
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Spin Labels
Grant Support
ID/Acronym/Agency:
5P30NS045839/NS/NINDS NIH HHS; AG15116/AG/NIA NIH HHS; AG17586/AG/NIA NIH HHS; NS44266/NS/NINDS NIH HHS; NS53488/NS/NINDS NIH HHS; P01 AG017586/AG/NIA NIH HHS; P30 NS045839/NS/NINDS NIH HHS; P50 NS053488/NS/NINDS NIH HHS; R01 AG015116/AG/NIA NIH HHS; R01 NS044266/NS/NINDS NIH HHS; R03 DA023496/DA/NIDA NIH HHS; R03DA023496/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Spin Labels
Comments/Corrections

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