Document Detail


Distinct activation of monoaminergic pathways in chick brain in relation to auditory imprinting and stressful situations: a microdialysis study.
MedLine Citation:
PMID:  9135059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the forebrain of the domestic chick (Gallus gallus domesticus), an area termed the mediorostral neostriatum/hyperstriatum ventrale is strongly involved in emotional learning paradigms such as acoustic filial imprinting. Furthermore, the involvement of the mediorostral neostriatum/hyperstriatum ventrale in stressful situations, such as social separation, has been demonstrated in 2-deoxyglucose studies. The aim of the present study was to examine whether quantitative changes of dopamine, serotonin and their metabolites occur during auditory filial imprinting and during social separation. Using in vivo microdialysis in tone-imprinted and in naive, control chicks, we compared the extracellular levels of homovanillic acid, a metabolite of dopamine, and 5-hydroxyindoleacetic acid, a metabolite of serotonin, during the presentation of the imprinting tone. A small, but statistically significant, decrease of extracellular homovanillic acid levels was found in the mediorostral neostriatum/hyperstriatum ventrale of imprinted chicks compared to control animals, whereas changes of 5-hydroxyindoleacetic acid were not detected. In a second experiment, we investigated the levels of homovanillic acid and 5-hydroxyindoleacetic acid in the mediorostral neostriatum/hyperstriatum ventrale of socially reared chicks during different stress situations, such as handling or separation from their cage mates. Handling induced a significant increase of homovanillic acid and 5-hydroxyindoleacetic acid, while social separation resulted in a significant increase of 5-hydroxyindoleacetic acid and only a slight increase of homovanillic acid. Despite considerable inter-individual variability, the increase of distress vocalizations (duration of distress calls) after social separation displayed a good correlation to the increased 5-hydroxyindoleacetic acid levels in all animals analysed. These results provide the first evidence that the physiological response of the mediorostral neostriatum/hyperstriatum ventrale related to different emotional conditions after acoustic imprinting and during stressful situations is, at least in part, mediated by dopaminergic and/or serotonergic pathways. Furthermore, the results from the present study indicate a distinct activation of dopaminergic and serotonergic pathways in relation to the behavioural situation and the associated changes of emotional status.
Authors:
M Gruss; K Braun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  76     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-07-21     Completed Date:  1997-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  891-9     Citation Subset:  IM    
Affiliation:
Federal Institute for Neurobiology, Neuromorphology, Magdeburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Biogenic Monoamines / metabolism,  physiology*
Brain Chemistry / physiology
Calcium / physiology
Chickens / physiology*
Female
Handling (Psychology)
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Imprinting (Psychology) / physiology*
Male
Microdialysis
Neural Pathways / physiology
Potassium / pharmacology
Prosencephalon / cytology,  physiology*,  physiopathology
Social Isolation
Stress, Psychological / metabolism,  physiopathology*
Tetrodotoxin / pharmacology
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 306-08-1/Homovanillic Acid; 4368-28-9/Tetrodotoxin; 54-16-0/Hydroxyindoleacetic Acid; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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