| Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth: lessons from mice and guinea pigs. | |
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MedLine Citation:
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PMID: 18191196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Placental insufficiency is thought to be a key factor in many cases of intrauterine growth restriction which complicates about 6% of pregnancies in western countries. Understanding the molecular control of placental and fetal growth is essential to identifying diagnostic and therapeutic targets to improve pregnancy success. Insulin-like growth factor (IGF)-I and IGF-II gene ablation or maternal food restriction reduce tissue and circulating IGF abundance in the fetus, placenta and mother and are associated with both placental and fetal growth restriction. Conversely, in vivo treatment of the pregnant guinea pig with IGF-I or IGF-II from early to mid pregnancy increases fetal weight and enhances placental transport near term. IGF-II, and an IGF2R specific analogue, enhanced placental structural differentiation, whereas IGF-I altered maternal body composition. These outcomes demonstrate endocrine roles within the mother for both IGFs, as well as autocrine/paracrine effects of IGF-II in enhancing placentation and pregnancy success. Therefore, factors that alter placental expression of IGF-II, or maternal circulating IGF-I or IGF-II in early pregnancy may affect placental exchange function late in gestation when the demands of the fetus escalate. IGF-II within the fetus may also signal its nutrient demands to the placenta to improve its function to suit. Therefore each IGF of endocrine and local origin has important, but distinct, roles in placental development and function. |
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Authors:
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C T Roberts; J A Owens; A N Sferruzzi-Perri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-01-11 |
Journal Detail:
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Title: Placenta Volume: 29 Suppl A ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-14 Completed Date: 2008-07-17 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: S42-7 Citation Subset: IM |
Affiliation:
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Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, S.A. 5005, Australia. claire.roberts@adelaide.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetal Development / physiology* Guinea Pigs Humans Insulin-Like Growth Factor I / physiology* Insulin-Like Growth Factor II / physiology* Mice Placenta / physiology* Pregnancy Receptor, IGF Type 1 / physiology Receptor, IGF Type 2 / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptor, IGF Type 2; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II; EC 2.7.10.1/Receptor, IGF Type 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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