Document Detail

Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation.
MedLine Citation:
PMID:  22695507     Owner:  NLM     Status:  MEDLINE    
Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes.
Tianxin Yang; Yaomin Du
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-06-14
Journal Detail:
Title:  American journal of hypertension     Volume:  25     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-20     Completed Date:  2013-02-01     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1042-9     Citation Subset:  IM    
Institute of Hypertension, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China.
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MeSH Terms
Blood Pressure / drug effects*
Dinoprostone / pharmacology*,  physiology*
Kidney / blood supply,  drug effects,  innervation
Receptors, Prostaglandin E / physiology
Receptors, Prostaglandin E, EP2 Subtype / drug effects,  physiology
Receptors, Prostaglandin E, EP3 Subtype / drug effects,  physiology
Receptors, Prostaglandin E, EP4 Subtype / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Receptors, Prostaglandin E; 0/Receptors, Prostaglandin E, EP2 Subtype; 0/Receptors, Prostaglandin E, EP3 Subtype; 0/Receptors, Prostaglandin E, EP4 Subtype; 363-24-6/Dinoprostone

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