| Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation. | |
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MedLine Citation:
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PMID: 22695507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes. |
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Authors:
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Tianxin Yang; Yaomin Du |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2012-06-14 |
Journal Detail:
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Title: American journal of hypertension Volume: 25 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-20 Completed Date: 2013-02-01 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 1042-9 Citation Subset: IM |
Affiliation:
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Institute of Hypertension, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China. yangtianxin@mail.sysu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Dinoprostone / pharmacology*, physiology* Humans Kidney / blood supply, drug effects, innervation Receptors, Prostaglandin E / physiology Receptors, Prostaglandin E, EP2 Subtype / drug effects, physiology Receptors, Prostaglandin E, EP3 Subtype / drug effects, physiology Receptors, Prostaglandin E, EP4 Subtype / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK079162/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Prostaglandin E; 0/Receptors, Prostaglandin E, EP2 Subtype; 0/Receptors, Prostaglandin E, EP3 Subtype; 0/Receptors, Prostaglandin E, EP4 Subtype; 363-24-6/Dinoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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