| Distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy. | |
| | |
MedLine Citation:
|
PMID: 20838948 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Hereditary and sporadic neurodegenerative ataxias are movement disorders that affect the cerebellum. Robust and objective biomarkers are critical for treatment trials of ataxias. In addition, such biomarkers may help discriminate between ataxia subtypes because these diseases display substantial overlap in clinical presentation and conventional MRI. Profiles of 10-13 neurochemical concentrations obtained in vivo by high field proton magnetic resonance spectroscopy ((1)H MRS) can potentially provide ataxia-type specific biomarkers. We compared cerebellar and brainstem neurochemical profiles measured at 4 T from 26 patients with spinocerebellar ataxias (SCA1, N = 9; SCA2, N = 7; SCA6, N = 5) or cerebellar multiple system atrophy (MSA-C, N = 5) and 15 age-matched healthy controls. The Scale for the Assessment and Rating of Ataxia (SARA) was used to assess disease severity. The patterns of neurochemical alterations relative to controls differed between ataxia types. Myo-inositol levels in the vermis, myo-inositol, total N-acetylaspartate, total creatine, glutamate, glutamine in the cerebellar hemispheres and myo-inositol, total N-acetylaspartate, glutamate in the pons were significantly different between patient groups (Bonferroni corrected p < 0.05). The best MRS predictors were selected by a tree classification procedure and lead to 89% accurate classification of all subjects while the SARA scores overlapped considerably between patient groups. Therefore, this study demonstrated multiple neurochemical alterations in SCAs and MSA-C relative to controls and the potential for these neurochemical levels to differentiate ataxia types. Studies with higher numbers of patients and other ataxias are warranted to further investigate the clinical utility of neurochemical levels as measured by high-field MRS as ataxia biomarkers. |
| | |
Authors:
|
Gülin Oz; Isabelle Iltis; Diane Hutter; William Thomas; Khalaf O Bushara; Christopher M Gomez |
Related Documents
:
|
19318738 - Reversible clinical and magnetic resonance imaging of central pontine myelinolysis foll... 9504478 - Neuroradiologic findings in marinesco-sjögren syndrome. 7727208 - Central pontine myelinolysis: report of an asymptomatic case. 12223378 - Prominent matched hypoperfusion in an intact cerebellum after a solitary middle cerebel... 2362958 - Angiography in lesions of the small bowel. 9232098 - Sinus pericranii associated with a cerebellar venous angioma--case report. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cerebellum (London, England) Volume: 10 ISSN: 1473-4230 ISO Abbreviation: Cerebellum Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101089443 Medline TA: Cerebellum Country: United States |
Other Details:
|
Languages: eng Pagination: 208-17 Citation Subset: IM |
Affiliation:
|
Center for MR Research, Department of Radiology, Medical School, University of Minnesota, 2021 6th St. S.E., Minneapolis, MN, 55455, USA, gulin@cmrr.umn.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An observational study of patient-rated outcome after atlantoaxial fusion in patients with rheumatoi...
Next Document: Behavioural significance of cerebellar modules.