Document Detail

Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
MedLine Citation:
PMID:  11906698     Owner:  NLM     Status:  MEDLINE    
Dentate gyrus granule cells innervate inhibitory interneurons via a continuum of synapses comprised of either Ca(2+)-impermeable (CI) or Ca(2+)-permeable (CP) AMPA receptors. Synapses at the extreme ends of this continuum engage distinct postsynaptic responses, with activity at CI synapses being strongly influenced by NMDA receptor activation. NMDARs at CI synapses have a lower NR2B subunit composition and a higher open probability, which generate larger amplitude and more rapid EPSCs than their CP counterparts. A novel form of NMDAR-dependent long-term depression (iLTD) is associated with CI-mossy fiber synapses, whereas iLTD at CP synapses is dependent on Ca(2+)-permeable AMPA receptor activation. Induction of both forms of iLTD required elevation of postsynaptic calcium. Thus mossy fibers engage CA3 interneurons via multiple synapse types that will act to expand the computational repertoire of the mossy fiber-CA3 network.
Saobo Lei; Chris J McBain
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  33     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  921-33     Citation Subset:  IM    
Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Anticonvulsants / pharmacology
Calcium / metabolism
Chlorides / metabolism
Cyclopropanes / pharmacology
Excitatory Amino Acid Antagonists / pharmacology
Excitatory Postsynaptic Potentials / physiology
Glycine / analogs & derivatives*,  pharmacology
Hippocampus / cytology,  physiology
Interneurons / cytology,  drug effects,  physiology*
Mossy Fibers, Hippocampal / drug effects,  physiology*
N-Methylaspartate / pharmacology
Patch-Clamp Techniques
Phenols / pharmacology
Piperidines / pharmacology
Polyamines / pharmacology
Protein Subunits
Rats, Sprague-Dawley
Receptors, AMPA / metabolism
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors,  metabolism*
Synaptic Transmission / physiology*
Valine / analogs & derivatives*,  pharmacology
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology
Reg. No./Substance:
0/Anticonvulsants; 0/Chlorides; 0/Cyclopropanes; 0/Excitatory Amino Acid Antagonists; 0/Phenols; 0/Piperidines; 0/Polyamines; 0/Protein Subunits; 0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate; 115976-93-7/philanthotoxin 343; 147782-19-2/2-(2,3-dicarboxycyclopropyl)glycine; 23210-56-2/ifenprodil; 56-40-6/Glycine; 6384-92-5/N-Methylaspartate; 7004-03-7/Valine; 7440-70-2/Calcium; 76326-31-3/2-amino-5-phosphopentanoic acid; 77521-29-0/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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