Document Detail


Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.
MedLine Citation:
PMID:  20980590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan meal ("satiety") and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor. We identified significantly different responses to these manipulations in amygdala, hypothalamus, and ventral striatum. Each region was specifically responsive to high-calorie compared to low-calorie food images. However, the ventral striatal response was attenuated by satiety (but unaffected by sibutramine), while the hypothalamic and amygdala responses were attenuated by drug but unaffected by satiety. Direct assessment of regional interactions confirmed the significance of this double dissociation. We explored the regional responses in greater detail by determining whether they were predictive of eating behavior and weight change. We observed that across the different regions, the individual-specific magnitude of drug- and satiety-induced modulation was associated with both variables: the sibutramine-induced modulation of the hypothalamic response was correlated with the drug's impact on both weight and subsequently measured ad libitum eating. The satiety-induced modulation of striatal response also correlated with subsequent ad libitum eating. These results suggest that hypothalamus and amygdala have roles in the control of food intake that are distinct from those of ventral striatum. Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect.
Authors:
Paul C Fletcher; Antonella Napolitano; Andrew Skeggs; Sam R Miller; Bruno Delafont; Victoria C Cambridge; Sanne de Wit; Pradeep J Nathan; Allison Brooke; Stephen O'Rahilly; I Sadaf Farooqi; Edward T Bullmore
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-28     Completed Date:  2010-11-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14346-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adiposity / drug effects
Adult
Amygdala / drug effects,  physiology
Appetite Depressants / pharmacology*
Basal Ganglia / drug effects,  physiology
Body Weight / drug effects
Brain / drug effects,  physiology*
Cyclobutanes / pharmacology*
Double-Blind Method
Energy Intake / physiology
Feeding Behavior / drug effects
Female
Food*
Humans
Hypothalamus / drug effects,  physiology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Overweight / psychology
Photic Stimulation
Satiety Response / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
064351//Wellcome Trust; G0502115//Medical Research Council; G0900554//Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Cyclobutanes; WV5EC51866/sibutramine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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