| Distinct Changes in Serum Fibroblast Growth Factor 21 Levels in Different Subtypes of Diabetes. | |
| | |
MedLine Citation:
|
PMID: 22013098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aims:Fibroblast growth factor (FGF) 21 is an endocrine factor with multiple beneficial effects on glucose and lipid metabolism in animals. This study aimed to investigate the association of serum FGF21 levels with type 1 diabetes, latent autoimmune diabetes in adults (LADA) and type 2 diabetes.Methods:Serum FGF21 levels were determined by ELISA in patients with type 1 diabetes (n = 76), LADA (n = 68), type 2 diabetes (n = 77), and their age- and sex-matched controls. The association of serum FGF21 with markers of autoimmunity was studied.Results:In type 1 diabetic patients, serum FGF21 levels were significantly lower than controls [108.3 (61.5-180.1) vs. 196.0 (103.7-330.9) pg/ml, P < 0.001]. In LADA patients, serum FGF21 levels were significantly lower than controls after adjustment for body mass index [210.9 (121.4-441.6) vs. 268.3 (159.5-443.6) pg/ml, P = 0.003]. By contrast, serum FGF21 levels in type 2 diabetic patients were significantly higher than controls [381.2 (244.7-531.3) vs. 301.4 (173.9-444.2) pg/ml, P = 0.006]. FGF21 levels increased progressively from type 1 diabetes, LADA, to type 2 diabetes (P < 0.001 for global trend). Furthermore, FGF21 levels correlated inversely with titers of glutamic acid decarboxylase and insulinoma-associated protein 2 autoantibodies in type 1 diabetic and LADA patients.Conclusions:Serum FGF21 level is increased in type 2 diabetes but decreased in type 1 diabetes and LADA. In autoimmune diabetes, the reduction in circulating FGF21 is closely associated with markers of pancreatic β-cell autoimmunity. |
| | |
Authors:
|
Yang Xiao; Aimin Xu; Lawrence S C Law; Cheng Chen; Hui Li; Xia Li; Lin Yang; Shiping Liu; Zhiguang Zhou; Karen S L Lam |
Related Documents
:
|
6821488 - The effect on mortality of low-dose insulin therapy for diabetic ketoacidosis. 22059988 - Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an inn... 6775998 - Ketoacidosis in ethiopian diabetics. 16215358 - Diabetic ketoacidosis in pregnancy. 18695598 - The impact of intensive insulin protocols and restrictive blood transfusion strategies ... 6952678 - Pathomorphological observations of gunshot wounds. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-19 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Diabetes Center (Y.X., H.L., X.L., L.Y., S.L., Z.Z.), Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan 410081, China; Departments of Medicine (A.X., L.S.C.L., C.C., K.S.L.L.) and Pharmacology and Pharmacy (A.X.) and Research Center of Heart, Brain, Hormone, and Healthy Aging (Y.X., A.X., K.S.L.L.), University of Hong Kong, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Illusory correlations in patient stereotyping.
Next Document: Moderate Alcohol Consumption and 24-Hour Urinary Levels of Melatonin in Postmenopausal Women.