| Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance. | |
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MedLine Citation:
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PMID: 22275086 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To characterize the defects in β-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, β-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured with the model by Mari in 172 Mexican Americans. A subgroup (n = 70) received a 2-h hyperglycemic clamp (+125 mg/dL), and first- and second-phase insulin secretion were quantitated. Compared with NGT, subjects with IFG and IGT manifested a decrease in β-cell glucose sensitivity; IFG subjects, but not IGT subjects, had decreased β-cell rate sensitivity. In IFG subjects, the defect in β-cell glucose sensitivity was time dependent, began to improve after 60 min, and was comparable to NGT after 90 min. The incremental area under the plasma C-peptide concentration curve during the first 12 min of the hyperglycemic clamp (ΔC-pep[AUC](0-12)) was inversely related with the increase in FPG concentration (r = -36, r = 0.001), whereas ΔC-pep[AUC](15-120) positively correlated with FPG concentration (r = 0.29, r < 0.05). When adjusted for the prevailing level of insulin resistance, first-phase insulin secretion was markedly decreased in both IFG and IGT, whereas second-phase insulin secretion was decreased only in IGT. These results demonstrate distinct defects in β-cell function in IFG and IGT. |
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Authors:
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Mustafa Kanat; Andrea Mari; Luke Norton; Diedre Winnier; Ralph A Defronzo; Chris Jenkinson; Muhammad A Abdul-Ghani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes Volume: 61 ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 447-53 Citation Subset: AIM; IM |
Affiliation:
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Corresponding author: Muhammad A. Abdul-Ghani, abdulghani@uthscsa.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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