Document Detail


Distention-produced phospholipid secretion in postmortem in situ lungs of newborn rabbits. Inhibition by specific beta-adrenergic blockade.
MedLine Citation:
PMID:  6688707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The secretion of total phospholipid in postmortem in situ lungs of newborn rabbits was examined using the technique of lung lavage after an initial lavage procedure, and then after a period of static air inflation at 30 cm H2O pressure for 45 min. There was a significant reduction in the phospholipid yield with 10(-3) molar DL-propranolol used as the initial lavage fluid, both immediately after the initial lavage procedure (experimental group, 0.29 +/- SE 0.04 mg/g dry lung weight; control group, 0.57 +/- SE 0.09; p less than 0.01) and after static inflation with air (experimental group, 1.14 +/- SE 0.15; control group, 2.22 +/- SE 0.24; p less than 0.001). Preinjection of the breathing newborn rabbit with DL-propranolol was not necessary for this inhibitory effect. There was no significant reduction when 10(-3) molar atropine, lidocaine, D-propranolol, or 10(-5) scopolamine were substituted as the initial lavage fluid, nor was there any reduction when the concentration of DL-propranolol was decreased to 10(-4) or 10(-5) molar. Because D-propranolol has all the properties of DL-propranolol, except 100-fold less beta-adrenergic antagonist activity, the inhibition by propranolol was due to specific beta-adrenergic blockade. In the absence of an intact circulation or a functional central nervous system, it is concluded that surfactant phospholipid secretion is partly controlled by an intrapulmonary neurogenic reflex.
Authors:
A Corbet; J Cregan; J Frink; A J Rudolph
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  128     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  695-701     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Female
Irrigation
Lung / drug effects,  innervation,  secretion*
Phospholipids / secretion*
Pregnancy
Propranolol / pharmacology
Pulmonary Surfactants / secretion*
Rabbits
Grant Support
ID/Acronym/Agency:
RR-05425/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Phospholipids; 0/Pulmonary Surfactants; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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