Document Detail

Distant haemorrhagic effects in intra-arterial tissue plasminogen activator--the effect of a bolus dose.
MedLine Citation:
PMID:  7707276     Owner:  NLM     Status:  MEDLINE    
Details are reported of four patients who developed serious distant haemorrhagic complications while undergoing peripheral arterial thrombolysis with intra-arterial tissue plasminogen activator (t-PA). The thrombolytic regime comprised a 20 mg bolus of t-PA followed by a continuous infusion of 1 mg/hr. Four additional cases of haemorrhage at the catheter entry site were also encountered in a group of 23 patients exposed to the bolus-infusion t-PA regimen. The high haemorrhage rate (31%) is a significant disadvantage of this thrombolytic protocol.
N P Cripps; A S Ward
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Royal Naval Medical Service     Volume:  80     ISSN:  0035-9033     ISO Abbreviation:  J R Nav Med Serv     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-11     Completed Date:  1995-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503111     Medline TA:  J R Nav Med Serv     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Royal Naval Hospital, Haslar.
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MeSH Terms
Aged, 80 and over
Arterial Occlusive Diseases / drug therapy
Drug Administration Schedule
Hemorrhage / chemically induced*
Infusions, Intra-Arterial
Middle Aged
Thrombolytic Therapy / adverse effects*
Tissue Plasminogen Activator / administration & dosage,  adverse effects*
Reg. No./Substance:
EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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