Document Detail


Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake. I. Structural changes.
MedLine Citation:
PMID:  7116409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The baso-lateral cell-membrane area in kidney tubules appears to be associated with the capacity for electrolyte transport; in the rabbit, it decreases from the distal convoluted tubule (DCT-cells) over the connecting tubule (CNT-cells) to the cortical collecting duct (principal cells). Adaptation to low Na-, high K-intake changes this pattern: CNT-cells at the beginning of the connecting tubule have the highest membrane area, which decreases along the segment, but remains two-fold higher than in controls. Principal cells have a four-fold higher membrane area than in controls. Simultaneous treatment with the antimineralocorticoid canrenoate-K inhibits the structural changes in CNT-cells only in end-portions of the connecting tubule and in principal cells. After prolonged high Na-, low K-intake DCT-cells display a two-fold higher membrane area than controls, while CNT-cells and principal cells are not affected. Simultaneous treatment with DOCA does not affect the DCT-cells but provokes a moderate increase in membrane area in CNT-cells, and a 5.5-fold increase in principal cells. The data provide evidence that DCT-, CNT- and principal cells are functionally different cell types. The baso-lateral cell-membrane area, associated with electrolyte-transport capacity, appears to be influenced in DCT-cells mainly by Na-intake, in CNT-cells mainly by K-intake and in part also by mineralocorticoids, and in principal cells mainly by mineralocorticoids.
Authors:
B Kaissling; M Le Hir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue research     Volume:  224     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  469-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Aldosterone / blood
Animals
Cell Membrane / ultrastructure
Desoxycorticosterone / pharmacology
Diet*
Diet, Sodium-Restricted
Female
Kidney Tubules / ultrastructure*
Kidney Tubules, Collecting / ultrastructure
Kidney Tubules, Distal / ultrastructure*
Microscopy, Electron
Mitochondria / ultrastructure
Potassium / administration & dosage*,  urine
Rabbits
Sodium / administration & dosage*,  urine
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; 64-85-7/Desoxycorticosterone; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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